Both Ahkmenrah and Kahmunrah endured from the results of Egyptian imperial incest and also inbreeding.

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tl;dnr: What it says on the tin.

Incest the the Egyptian Royals

Egyptian royalty, for centuries, was renowned for their techniques of inbreeding and incest. Because that generations, brothers (Pharaohs) to be traditionally intended to marry your sisters or half-sisters in order come "keep the imperial bloodline pure".

This is because, according to Egyptian mythology, the royals were believed to descend from the gods, and also were revered as "gods" themselves. Particularly, Osiris, "Lord that the Underworld", and also his wife, Isis, the king and queen of the Egyptian pantheon, were claimed to have actually been "brother and sister".

Kahmunrah also says in Night in ~ the Museum: fight of the Smithsonian:

"I am Kahmunrah, half-god, when removed on mine mother's side. Rightful ruler of Egypt and future ruler of... Every little thing else."

(For reference, your first cousin once removed is the son - or parental - of your first cousin.)

The most famous Egyptian royals, King Tutankhamun and Queen Cleopatra VII, were also products of imperial incest and also inbreeding. Particularly, Tutankhamun had a club foot, walked through a limp, "had a feminine, curvy body", and also suffered indigenous several hereditary issues. Cleopatra was also far native the "great beauty" the she was stated to it is in today, having actually a "big nose" and also "rather unremarkable / plain", together per account from Plutarch:

"Her very own beauty, therefore we room told, was no of the incomparable type that automatically captivates the beholder. However the charm that her existence was irresistible and there was an attraction in she person and in she conversation that, along with a peculiar force of character in her every word and action, laid every who connected with her under her spell." (Source)

The Night at the Museum: fight of the Smithsonian game also featured Cleopatra as well:

The video clip game complies with the story but include a couple of details. There, Kahmunrah shatters the golden Tablet and also give its pieces to his men, to avoid Larry from using it, forcing him to take every one of them back. Also, Larry will run into Cleopatra’s wax statue and must acquire her the fabled expect Diamond to learn a secret about the Tablet. (Source)

Even follow to the Smithsonian's main magazine, genetic testing of King Tut's DNA showed very clear proof of the effects of generations that inbreeding.

The Negative, biological Effects the Inbreeding

So, as we understand that both Kahmunrah and also his brother, Ahkmenrah, ruled together Pharaohs at one point, and were the children of imperial parents...chances are, their parents were very closely related, if not brother and sister.

While neither Ahkmenrah no one Kahmunrah have any type of apparent physical effects - according to existing science, that takes number of generations of repetitive inbreeding to present - ns theorize that the rampant inbreeding in the Egyptian imperial line likely negatively effected Kahmunrah.

More specifically, Kahmunrah most likely inherited "insanity", and other mental difficulties / issues, bring about his meglomaniacal, psychotic, also psychopathic behavior. Follow to his own words, throughout his rule, the was recognized as "Kahmunrah the Bloodthirsty".

From one answer on Quora:

Clarification: Inbreeding depression doesn't mean a psychological depression. It means the biological fitness the inbred offspring is lowered ("depressed") when rare harmful recessive alleles are carried together. The harmful recessives might have an result on psychology, though.

Inbreeding depression: as soon as an individual's ancestors overlap, the very same alleles native the exact same ancestor deserve to be current in 2 copies and thus the recessive phenotype is uncovered. Because that example, if two half-siblings have a boy together, that child only has three grandparents. The double-grandparent has two opportunities to pass under alleles to the very same grandchild.

So, if the double-grandparent had actually a rare, harmful recessive allele that was spanned up by a dominant wild-type allele, lock would more than likely never know, but their double-grandchild can inherit the recessive allele double (one indigenous the mother and also once indigenous the father, who each inherited the from their mutual parent), and have the recessive phenotype.

The recessive allele is rarely in the basic population, and also there space usually plenty of such alleles in a populace that nearly never cause harm due to the fact that they are never homozygous. Inbreeding is the main way that these harmful recessive phenotypes come to light.

So, inbreeding can absolutely have psychological results if the recessive alleles that are brought together have actually an effect on the brain. because the brain is facility piece of machinery and also many, plenty of things can affect its function, there are countless ways in which inbreeding can reason cognitive abnormalities.

This examine ("Estimating the Inbreeding Depression on Cognitive Behavior: A populace Based research of child Cohort") discovered that psychological retardation and also cognitive deficiencies increased with the degree of inbreeding in the cohort lock studied. Together you deserve to see, the tendency was striking.

The over study was measuring IQ, but many determinants go right into determining one's performance on an IQ test so it's measure up the effects of too many of various uncovered phenotypes. There is no one specific psychological or cognitive feature that is connected with inbreeding-- any kind of recessive disorder can be uncovered by inbreeding and virtually any kind of gene can harbor a harmful recessive.

As such, given that DNA testing has revealed that King Tut experienced from generations that inbreeding, that seems like a shoe-in to assume the Kahmunrah likewise suffered from similar defective alleles - albeit psychologically.

However, even despite seeming lack of physical defects from inbreeding, I would certainly argue that, perhaps, both Ahkmunrah and Kahmunrah endured from these results in life. This is because, as opposed to gift a mannequin, Ahkmenrah's own, dead reanimated and "comes ago to life" with the magic of the Tablet.

(On the other hand, Kahmunrah, due to not transforming into a mummy after Night 1, is most likely a wax statute artist's translate / forensic recreation of the initial Kahmunrah.)

King Tutankhamun together an Example

Again, ns will usage the example of King Tut. Despite he lived right into his teens, and appeared "relatively healthy", his DNA still yielded a organize of genetic and also physical (congenital) problems, consisting of the abovementioned club foot, limp, etc. However, under Tut's surface appearance, he likewise suffered physically:

King Tutankhamen, recognized as Egypt's boy pharaoh, more than likely spent lot of his life in pain prior to dying at 19 indigenous the linked effects that malaria and a damaged leg, scientists say.

Tut likewise had a slot palate and a curved spine, and also was more than likely weakened by inflammation and problems through his immune system, castle say.

The conclusions originates from a new study that offered molecular genetics and progressed CT scanning to study 11 royal mummies from old Egypt. The research was released in the Journal of the American medical Association.

<...> The tests walk reveal sufficient physical difficulties to difficulty the idea the this young king had simple life. "This man was suffering," Pusch says.

The study's greatest surprise entails Tut's left foot, Pusch says. It was clubbed. And also some bones in the toes to be dying indigenous a degenerative disease. That would describe why Tut's dig contained an ext than 100 canes or walking sticks, Pusch says.

The degenerative bone condition probably caused Tut's foot come swell native inflammation and made it impossible for him come walk normally, Pusch says.

<...> The difficulties related to inbreeding probably contributed to Tut's death yet were no the instant cause, Pusch says. Earlier studies had found that Tut had a badly broken right leg, which might have been a factor.

"He also had a raging instance of malaria," claims Howard Markel, that wrote one editorial around the brand-new study and also is the George E. Wantz professor that the background of medicine at the college of Michigan. The new study uncovered DNA in Tut's bones indigenous the parasite responsible for the many severe form of malaria.

It's likely, though no certain, that the mix of a damaged bone, malaria and underlying health troubles is what eliminated King Tut, Markel says. (Source)

That being said, the is most likely quite most likely that inbreeding had a detrimental impact on King Tut's immune system, at some point killing him by rendering him much more susceptible to malaria. He died at period 19.

Similarly, Ahkmenrah is a very clear analogue because that King Tutankhamun. This is because both are portrayed as young men; previous, "famous" Pharaohs the Egypt; and, if Ahkmenrah's young age is to it is in believed, both died at young eras as well.

Ahkmenrah's clothes and also headdress additionally seem very obviously based upon King Tut's. Ahkmenrah's name additionally likely originates from Akhmim, the birthplace the King Tut's royal advisor and also successor, the Pharaoh Ay (Kheperkheperure), and also the god Rah, the Egyptian god the the sun. (Ay's royal name additionally meant "Everlasting are the Manifestations that Ra(h)".)

The Night in ~ the Museum Wiki additionally states:

Ahkmenrah wasn't an really pharaoh in Egyptian History, and is not visibly based upon any specific pharaoh. The is conceivable that some impetus was taken from King Tutankhamun, the boy King, another very young pharaoh that ruled and also died unexpectedly from some unusual cause. (Source)

That gift said, Kahmunrah also seems somewhat based upon King Tut's imperial advisor, Ay - albeit top top Egyptologist Bob Brier's fictionalized account that Ay.

Egyptologist Bob Brier argued that Ay murdered Tutankhamun in order to usurp the throne, a claim which was based upon X-ray examinations the the body done in 1968.

He additionally alleged the Ankhesenamun, King Tut's widow, and also the Hittite Prince she was about to marry were also murdered at orders.

This murder theory was not accepted by every scholars, and much more detailed CT-scans the the mummy undertaken through National geographical (published in late 2005) suggested that Tutankhamun did no die indigenous a punch to his head together Brier had theorized.

The National geographical forensic researchers rather presented a new theory that Tutankhamun died from one infection brought about by a badly broken leg because he is often shown as walking v a cane due to spina bifida, a hereditary characteristics in his family members on his father's side.

When the results of the CT-Scan examination had been published, plenty of scientists welcomed its findings, but some still think the mystery of Tutankhamun's fatality is much from solved and also continue to assistance the older murder theory. Over there are publications that have subsequently been published that adhere to the initial murder theory and also dispute the conclusions got to by the CT scan team, though additionally citing other means of murder, such together poisoning.

Ay was additionally buried in the dig intended for Tutankhamun in the West valley of the monarchs (KV 23), and also Tutankhamun in Ay's intended dig in the east Valley of the kings (KV 62). (Source)

An at an early stage version the the script likewise had Kahmunrah claim he murdered Ahkmenrah:

In an early version of the manuscript for Battle the the Smithsonian, during a conversation with Larry, Kahmunrah reveals that he murdered Ahkmenrah. (Source)

In conclusion...

Whether or no Kahmunrah eliminated his younger brother, Ahkmenrah - the two's parents provided the throne to Ahkmenrah in lieu that Kahmunrah, likely due to the latter's psychotic tendencies - the truth remains: both Ahkmenrah and Kahmunrah appear relatively young for former rulers the Egypt. Thus, is have the right to be logically inferred that both died young.

Given the evidence presented because that inbreeding play a large role in King Tut's death, and also Ahkmenrah's obvious similarities come King Tut, it more cements the liklihood the Ahkmenrah might have died young - not by Kahmunrah's "bloodthirsty" hand - yet due to the merged effects the inbreeding and also disease, choose Tut.

Likewise, if inbreeding affected both Tut and Ahkmenrah, then further supports the Ahkmenrah's older brother, Kahmunrah, also suffered from comparable effects - albeit likely an ext psychologically.

It appears that Kahmunrah likewise went the method of King George III, who was additionally said to have actually suffered the psychological / mental results of inbreeding:

King George III the England, whose reign was famously marked by losing the American Revolution, likely had a genetic disorder that influenced his mind much more noticeably than his body. That is a thought to have actually suffered native porphyria, a condition that provides a patient’s urine bluish purple and causes bouts of insanity (though arsenic poisoning and bipolar disorder have additionally been argued as feasible causes).

George III consistently checked out from his royal duties come escape come seclusion and private recovery in ~ Kew Palace. That was vulnerable to babbling delusions in his later on life and also subjected to excessive treatments consisting of strait-jackets, leeching, and ice baths to patience him. Contemporary medical experimentation shows porphyria was typical in the very inbred house of Hanover, come which King George III belonged. (Source)

On a next note, Ahkmenrah mentions to his parental "it's been around 4,000 years" due to the fact that he ruled. That would placed Ahkmenrah's preeminence as Pharaoh (hypothetically) about ~2000 (~2000 A.D. - 4000 = -2000). This would most likely make them an alternating Eleventh empire of Egypt. The reign of its critical king, and also thus the end of this dynasty, is something of a mystery. Modern-day records refer to "seven empty years" complying with the fatality of its second-to-last king, likely Kahmunrah's regime after his brother's passing.

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Likewise, Akhmenrah's parents mention the Jews in the 3rd film. One historical date for the Israelites start Egypt because that is 1986 B.C., towards the tail finish of the Eleventh Dynasty.