Medically reviewed by Cynthia Cobb, DNP, APRN, WHNP-BC, FAANP — Written by James McIntosh on June 16, 2017

Collagen is the many numerous protein in the humale body, found in the bones, muscles, skin, and also tendons.

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It is the substance that holds the body together. Collagen forms a scaffold to administer strength and also framework.

Endogenous collagen is herbal collagen, synthesized by the body. Exogenous collagen is man-made. It comes from an external resource, such as supplements.

Endogenous collagen has actually a variety of crucial attributes. Breakdvery own and depletion is connected to a variety of health and wellness troubles.

Exogenous collagen is used for medical and cosmetic objectives, including the repair of body tworries.


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Share on PinterestCollagen has a sturdy structure. Gram-for-gram, some forms are more powerful than steel.
Collagen is a difficult, insoluble, and fibrous protein that renders up one-third of the protein in the huguy body.

In a lot of collagens, the molecules are packed together to form long, thin fibrils.

These act as sustaining frameworks and anchor cells to each other. They offer the skin toughness and elasticity.

Tright here are at least 16 various kinds of collagen, however 80 to 90 percent of them belong to forms 1, 2, and 3. These different kinds have actually various frameworks and also features.

The collagens in the human body are solid and versatile.

Type 1 collagen fibrils are especially capable of being stretched. Gram-for-gram, they are more powerful than steel.


Roles: What does collagen do?

Collagen is secreted by miscellaneous cells, yet mostly by connective tconcern cells.

It is found in the extracellular matrix. This is an detailed netjob-related of macromolecules that determines the physical properties of body tproblems. A macromolecule is a molecule containing a huge number of atoms.


Share on PinterestWith age, collagen weakens, causing wrinkles and cartilage difficulties.

In the dermis, or the middle layer of skin, collagen helps create a fibrous netjob-related of cells called fibroblasts, upon which new cells have the right to thrive. It likewise plays a function in replacing and also restoring dead skin cells.

Some collagens act as protective coverings for delicate organs in the body, such as the kidneys.

With age, the body produces less collagen. The structural integrity of the skin declines. Wrinkles create, and joint cartilage weakens.

Woguys endure a dramatic reduction in collagen synthesis after menopausage.

By the age of 60 years, a significant decline in collagen manufacturing is normal.


Uses: Medical and cosmetic

Collagen is resorbable. This suggests it can be damaged down, converted, and soaked up back right into the body. It can additionally be formed right into compacted solids or lattice-like gels.

Its diverse selection of functions and the reality that it is naturally arising make it clinically versatile and suitable for assorted medical objectives.

Collagen for clinical use deserve to originate from people, cows, pigs, or lamb.

Skin fillers

Collagen injections have the right to enhance the contours of the skin and also fill out depressions.

Fillers that contain collagen have the right to be offered cosmetically to remove lines and wrinkles from the confront. It deserve to additionally improve scars, as long as these do not have actually a sharp edge.

These fillers are sourced from people and also cows. Skin tests need to be done prior to using collagen from cows, to prevent aggravating any allergies.

Collagen deserve to fill reasonably superficial volumes. More extensive gaps are normally filled via substances such as fat, silicone, or implants.

Wound dressing

Collagen can assist heal wounds by attracting brand-new skin cells to the wound site. It promotes healing and also gives a platdevelop for new tissue growth.

Collagen dressings have the right to help heal:

chronic wounds that do not respond to other treatmentwounds that expel bodily fluids such as urine or sweatgranulating wounds, on which various tproblem growsnecrotic or rotting woundspartial and also full-thickness woundssecond-level burnssites of skin donation and skin grafts

Collagen dressings are not recommended for third-degree burns, wounds extended in dry eschar, or for patients who may be sensitive to products sourced from cows.

Guided tconcern regeneration

Collagen-based membranes have been offered in periodontal and also implant therapy to promote the development of particular types of cell.

In oral surgery, collagen barriers can proccasion fast-prospering cells about the gum from migrating to a wound in a tooth. This preserves a room wbelow tooth cells have actually the opportunity to regenerate.

Collagen-based membranes deserve to help healing in these cases and they are resorbable, so this barrier does not must be surgically rerelocated after the major procedure.

Vascular prosthetics

Collagen tworry grafts from donors have been offered in peripheral nerve renewal, in vascular prostheses, and also in arterial reconstruction.

While collagen prostheses are compatible through the huguy body, some have been discovered to be thrombogenic, or most likely to cause coagulation of the blood.

Treatment of osteoarthritis

Collagen supplements or formulations might help treat osteoarthritis.

A 2006 evaluation found that supplements containing collagen assisted decrease painful symptoms and also improving joint function in people via osteoarthritis.

As the supplement was took in, collagen gathered in the cartilage, and this aided to reconstruct the extracellular matrix.

Not all researches have actually supported these findings, however.

Skin revitalization


Share on PinterestCollagen creams are unmost likely to job-related, as collagen molecules are also huge to pass through the skin.

Many products containing collagen, consisting of creams and powders, claim to revitalize the skin by boosting collagen levels within the body.

This is unmost likely, but, as collagen molecules are too large to be absorbed with the skin.

Any advantage is more than likely because of the moisturizing impacts of these products. They carry out not straight increase collagen.

Such treatments are also not classified as drugs, so any claims regarding their efficacy do not need to be scientifically proven. Caution is advised as soon as using these commodities.


Laser therapy have the right to help treat stretch marks, as it have the right to stimulate the growth of collagen, elastin, and also melanin.

A healthful diet deserve to aid the body develop collagen.

Nutrients that might support collagen formation include:

Copper: In shellfish, nuts, red meat, and also some drinking water.

What dameras collagen?

Some determinants deserve to diminish the levels of collagen within the body. Avoiding them could keep the skin healthy and balanced for much longer.

High sugar consumption: A high-sugar diet rises the rate of glycation, a process wright here blood sugars connect to proteins to create brand-new molecules dubbed progressed glycation finish assets (AGEs).

AGEs damages surrounding proteins and also have the right to make collagen dry, brittle, and also weak.

Smoking: Many kind of chemicals existing in tobacco smoke damage both collagen and elastin in the skin.

Nicotine additionally narrows the blood vessels in the external layers of the skin. This comassures skin health by reducing the delivery of nutrients and oxygen to the skin.

Sunlight: Ultraviolet rays in sunlight cause collagen to break down even more quickly, damaging collagen fibers and leading to abnormal elastin to build up.

The UV rays in sunlight damage the collagen in the dermis, and also the skin rebuilds erroneously, developing wrinkles.

Autoimmune disorders: Some autoimmune disorders cause antibodies to taracquire collagen.

Genetic changes have the right to influence the extracellular matrix. The collagen that is developed deserve to be reduced, or it might be dysuseful, mutated collagen.

The aging process reasons collagen levels to diminish naturally over time. Tright here is no way to proccasion this.

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Avoiding tobacco and also excess sun exposure and also adhering to a healthful dietary and also exercise routine can aid reduce visible aging and protect collagen, maintaining the skin, bones, muscles, and also joints healthy for longer.