By:Eishi Noguchi, Ph.D.(Department that Biochemistry and Molecular Biology, Drexel college College of Medicine)©2010yellowcomic.com Education


You are watching: Why is it important that exact copies of dna are produced during replication

Citation:Noguchi,E.(2010)The DNA Replication Checkpoint and also Preserving Genomic Integrity during DNA Synthesis.yellowcomic.com Education3(9):46
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The replication fork is an ext than just a means for DNA duplication. It is connected to a checkpoint device that keeps the genome intact and also prevents cancer.

Eukaryotic genomesare replicated with virtually absolute fidelity every time cells divide. However,conditions because that DNA replication are rarely ideal. Because that example, environmentaltoxins or drugs cause DNA damage and also interfere v DNA replication. Just how does acell circumvent such problems? exactly how does a cabinet generate precise copy ofgenetic products under such conditions?

During every celldivision, a cell must duplicate the chromosomal DNA through a procedure calledDNA replication. The copied DNA is then segregated into two "daughter"cells the inherit the same genetic information. This process is calledchromosome segregation. Since DNA is a depository of hereditary information, DNAreplication and segregation should be achieved with too much fidelity. Fail ofthese processes can reason mutations and also chromosome rearrangements, leading todiseases or even fatality (Abraham 2001;Kastan & Bartek 2004).

Healthy cell canperform DNA replication with nearly absolute accuracy many of the time.Considering that a eukaryotic bio cell includes millions or billions of DNA basepairs, this is a remarkable accomplishment. However, the problems for DNAsynthesis are hardly ever ideal, with number of obstacles challenging the DNAreplication machine (Branzei &Foiani 2007; Heller & Marians 2006; Lambert, Froget & Carr 2007). It seems that DNA replication is much more complicated than onemight think. So, what could interfere through DNA replication?